Media’s portrayal and framing of news related to human trafficking play a vital role in shaping public perception and opinions. The media also have key roles in steering discussions in the political sphere and policy formulations. In this context, this study aimed to understand the reported changes in international routes of human trafficking from Nepal for labour migration in the previous five years and examine the media portrayal of different actors involved in human trafficking, such as suspected victims and alleged perpetrators. Mixed methods were used to conduct the study, consisting of a review of existing data and publications on human trafficking, content analysis of news archives from six sampled national newspapers, and interviews with newspaper reporters and editors on issues surrounding human trafficking reporting. The study finds that India still remains the top trafficking destination, while countries in the Gulf Cooperation Council (GCC), North America, Europe, Southeast Asia and Australia have also been reported as new trafficking destinations. The paper further finds that Myanmar along with some countries in Europe, Africa and Latin America have emerged as new transits for human trafficking from Nepal. Labour trafficking and sex trafficking were the most reported examples of human trafficking. Most alleged perpetrators in the news reports were male, while females dominated reportage on ‘victims’.